Effects of Phytate and Phytase on the Performance and Immune Function of Broilers Fed Nutritionally Marginal Diets

    The effects of phytate and phytase on broiler performance and cellular and humoral immunity was assessed by using 504 Cobb 500 female broilers fed nutritionally marginal diets. At 1 d of age, the chicks were randomly allocated to 6 treatments in a 2 z 3 factorial arrangement including 2 levels of phytate P (0.22 or 0.44%) and 3 dose rates of an Escherichia coli-derived phytase [0, 500, or 1,000 phytase units (FTU)/kg of feed]. Both low- and high-phytate diets were corn and soy based with the same nutritional specifications (AME 2,900 kcal/kg, CP 21.00%, Ca 0.78%, and nonphytate P 0.28%), differing only in the concentration of phytate P. The immune status of birds was measured at 14, 21, and 28 d of age. The results revealed that phytase improved feed intake, BW, and feed conversion ratio (P < 0.05), whereas high dietary phytate depressed bird performance (P < 0.05). There was no interaction between phytate and phytase on bird performance. Feeding phytase increased the percentages of erythrocyte rosette-forming cells and erythrocyte-antibody complement cells by 3.03 and 1.83% at d 21, and by 2.76 and 2.20% at d 28, respectively (P < 0.05). The percentages of CD4+CD8+ T lymphocyte subsets were also increased by phytase (P < 0.05), without affecting the ratio of CD4+ and CD8+. The levels of intestinal secretary IgA were improved with phytase at d 14, 21, and 28 (P < 0.05). Antibodies against Newcastle disease virus vaccine were enhanced at d 21 and 28 in the high-phytate diets with phytase addition (P < 0.05). Increasing the phytase dose to 1,000 FTU/kg did not improve immune function further than 500 FTU/kg. The results suggest that application of phytase in nutritionally marginal diets could enhance lymphocyte numbers and the seral and mucosal antibodies of 1- to 28-d-old broilers, suggesting that both phytate and phytase may have a role in gastrointestinal health and immune competence
    Document information
    Product / service: Phytases
    Publication date: 01/01/2008
    Species: Poultry, Broiler
    Authors: Liu N, Ru YJ, Cowieson AJ, Li FD, Cheng XCH
    Doctype: Publications & Citations
    Publication / conference: Poultry Science, volume 87
    Regions and countries: Global
    Keywords: age, ame, antibodies, antibody, application, birds, broiler, performance, broilers, bw, ca, chick, chicks, concentration, conversion, corn, cp, diet, dietary, diets, disease, dose, rate, effects, feed, ratio, intake, feeding, female, function, gastrointestinal, health, humoral, immunity, iga, immune, competence, status, interaction, lymphocyte, newcastle, p, phytase, phytate, secretory, soy, treatment, vaccine, virus
    Production challenge(s): Gut health
    Diets: All diets
    Brands: Axtra® PHY, Phyzyme® XP, Optimize Feed, Phycheck, FASTKit assay
    Resource ref: 9905
    This material is related to a conference
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