Structural and functional characterization of ochratoxinase, a novel mycotoxin-degrading enzyme

    Ochratoxin, with ochratoxin A as the dominant form, is one of the five major mycotoxins most harmful to humans and animals. It is produced by Aspergillus and Penicillium species and occurs in a wide range of agricultural products. Detoxification of contaminated food is a challenging health issue. This paper shows that A. niger Otase's high efficacy and thermostability makes it a promising new agent for enzymatic detoxification of ochratoxinase-contaminated agricultural products.
    Document information
    Product / service: Enzymes
    Publication date: 20/06/2014
    Species: Poultry, Pig, Ruminants, Aquaculture
    Authors: Yu S, Schneider, G, Dobritzsch, D, Wang, H
    Doctype: Publications & Citations
    Publication / conference:
    Regions and countries: Global
    Keywords: protein, ochratoxinase, ochratoxin degradation, protein crystal structure, Aspergillus, Penicillium, active site segment, carboxypeptidase A, 4MF, N-(4-methoxyphenylazoformyl)-phenylalanine, non-crystallographic symmetry, ochratoxin A
    Production challenge(s): food safety
    Diets: All diets
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