Campylobacter jejuni is not merely commensal in commercial broiler diets

    Campylobacter jejuni is the leading cause of bacterial food-borne infection; chicken meat is its main source. C. jejuni is considered commensal in chickens based on experimental models unrepresentative of commercial production. This paper shows that the paradigm of Campylobacter commensalism in the chicken is flawed. Through experimental infection of four commercialbreeds of broiler chickens, we show that breed has a significant effect on C. jejuni infection and the immune response of the animals, although these factors have limited impact on the number of bacteria in chicken ceca. All breeds mounted an innate immune response. In some breeds, this response declined when interleukin-10 was expressed, consistent with regulation of the intestinal inflammatory response, and these birds remained healthy. In another breed, there was a prolonged inflammatory response, evidence of damage to gut mucosa, and diarrhea. We show that bird type has a major impact on infection biology of C. jejuni. In some breeds, infection leads to disease, and the bacterium cannot be considered a harmless commensal. These findings have implications for the welfare of chickens in commercial production where C. jejuni infection is a persistent problem."
    Document information
    Product / service: Probiotics
    Publication date: 01/07/2014
    Species: Poultry
    Authors: Humphrey, S, Chaloner, G, Kemmett, K
    Doctype: Publications & Citations
    Publication / conference: MBio/ASM.org
    Regions and countries: Global
    Production challenge(s): Gut health, Performance growth, Increased profitability
    Diets: Corn, broken rice, wheat, Corn, broken rice, sorghum, Wheat, rye & triticale, Wheat, rye and tricale containing by-products, Corn & soybean meal & high fibre by-products., Corn & sorghum meal & high fibre by-products., Corn & soybean meal , Corn & sorghum meal, Maize
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